1.Central Dogma is proposed by-
(1) Watson
(2) Crick
(3) Franklin
(4) wilkins
2. Nuclein term was coined by-
(1) Griffith
(2) messelson and stahl
(3) Meischer
(4) Chargaff
3. Which of the following is not according to Chargaff -
(1) A/T = G/C
(2) A+G / T+C
(3) A/G = T/C
(4) A+T /G+C
4.Diameter of B-type DNA is -
(1) 0.34nm
(2) 2nm
(2) 3.4nm
(4) none
5.DNA have uniform diameter because-
(1) DNA is right handed coil
(2) DNA is double stranded
(3) In DNA purine always base pair with pyrimidine
(4) DNA have four bases
6.Proteins help in packaging in prokaryotes-
(1) Polyamines
(2) histones
(3) NHCs
(4) Lamins
7.Histone octamer have all except-
(1) H2 A
(2) H2 B
(3)H3
(4) H1
8. Dimensions of octamer is -
(1) 10nm x 5nm
(2) 20nm x 5nm
(3) 146nm x 200nm
(4) 300nm x 400nm
9. Amount of DNA wrap over histone octamer is-
(1) 13/4 turn
(2) 22/3turn
(3) 1.75 turn
(4) both 1 and 3
Q55. Nucleosome have all except -
(1) H2A, H2B and H1
(2) Core DNA and H1
(3) H3 and H4
(4) linker DNA and NHCs
Q56.Length of DNA wrap over octamer is -
(1) 147bp
(2) 189bp
(3) 120bp
(4) 300bp
Q57.Length of DNA present in nucleosome is -
(1) 134bp
(2) 146bp
(3) 120bp
(4) 200bp
Q58.Which is incorrect matched related to packaging of DNA-
(1) DNA - 2nm fibre
(2) Nucleosome- 10nm fibre
(3) solenoid- 30nm fibre
(4) chromatid - 1400nm fibre
Q59.Protein other than histone help in packaging is known as -
(1) tubulin
(2) lysine
(3) Non histone chromosomal protein
(4) None
Q60 Base ratio( A+T/G+C ) is use to determine the stability of DNA
as-
(1) More GC content more stable is DNA
(2) More AT content more stable is DNA
(3) More double bonr more stable is DNA
(4) None
Q61. E.coli DNA is stable than Human DNA as-
(1) base ratio less than 1
(2) base ratio equal to 1
(3) base ratio more than 1
(4) all
Q62. Which of the following was discovered by temin as modification
of central dogma-
(1) DNA replication
(2) transcription
(3) translation
(4) reverse transcriprion
Q63. For which of the following process RNA act as template-
(1) Transcription
(2) Replication
(3) Reverse transcription
(4) primer synthesis
Q64. Which of the amino acid present in histone-
(1) lysine and tryptophan
(2) arginine and seriene
(3) glycine
(4) all
Q65. Which of the amino acid rich in histone-
(2) lysine and arginine
(2) lysine and seriene
(4) Histidine and glycine
(4) all
Q66. Which of the following is transcriptionally inactive-
(1) heterochromatin
(2) Euchromatin
(3) chromosome
(4) both 1 and 3
Q67. According to griffith transforming principle is -
(1) DNA
(2) RNA
(3) protein
(4) unknown
Q68. If heat killed R-strain of streptococcus along with live R-strain injected in mice than which is true-
(1) mice die due to Pnemonia and transformation occur
(2) Mice alive and transformation occur
(3) Mice die due to pnemonia and no trasformation occur
(4) Mice die due to pnemonia and from dead mice live R-strain obtained
Q69.Smooth strain of streptococcus S-strain is due to -
(1) protein
(2) mucopolysaccharide
(3) lipid
(4) nucleic acid
Q70.DNA is transforming principle is proved by-
(1)Avery , Mccarty, Macloed
(2) Griffith
(3) both 1 and 2
(4) harsey and chase
Q71.Purified biochemicals from heat killed S-strain contain-
(1) DNA and lipid
(2) DNA,RNA and protein
(3) Nucleic acid and lipid
(4) all
Q72. Which of the following inference can not be drawn from experiment of griffith-
(1) Transforming principle is thermostable
(2) Transforming principle enter into cell from medium
(3) Transforming principle is DNA
(4) Transforming principle can change expression of R-strain
Q73.One gene one enzyme hypothesis is given by-
(1) beadle and tatum
(2) griffith
(3) Ingram
(4) messlson and stahl
Q74..One gene one polypeptide hypothesis is given by
(1)beadle and tatum
(2) Ingram
(3) Griffith
(4) messlson and stahl
Q75.Correct sequence in Blending experiment of harshey and chase-
(1) centrifugation, blending, infection
(2) Infection, blending, centrifugation
(3) Centrifugation, blending, infection
(4) Infection, blending and centrifugation
Q76. Radioisotope incorporated in protein during blending experiment is-
(1) S
35
(2) P32
(3) I
32
(4) none
Q77.Bacteriophage with radiolabled protein , than after centrifugation radioactivity appears during harshey and chase experiment-
(1) radioactive sulphur in pellet
(2) radioactive phosphorus in supernatant
(3) radioactive sulphur in supernatant
(4) radioactive phosphorus in pellet
Q78. If Radioactivity of phosphorus is observed in supernatant in
harshey and chase experiment than which might be inference-
(1) DNA is genetic material
(2) RNA is genetic material
(3) Protein is genetic material
(4) All
Q79. RNA is genetic material in -
(1) QB bacteriophage
(2) TMV
(3) HIV
(4) all
Q80. Which feature of genetic material is useful for evolution-
(1) slow change
(2) express itself
(3) chemically stable
(4) generate its replica
Q81.Ability to make its copies present in-
(1) DNA
(2) RNA
(3) proteins
(4) both 1 and 2
Q82 2’-OH group in RNA have effect -
(1) make it labile
(2) prone to degradation
(3) make it reactive
(4) all
Q83. Mark the incorrect statement-
(1) DNA is chemically less reactive than RNA
(2) DNA is structurally more stable than RNA
(3) DNA is not catalytically active
(4) RNA is catalytically inactive
Q84 Which of the following is least thermostable -
(1) DNA
(2) RNA
(3) protein
(4)all
Q85.DNA evolved from RNA by-
(1) chemical modification
(2) structural change
(3) both 1 and 2
(4) none
Q86.For transmission of character which is better -
(1)DNA
(2) RNA
(3)protein
(4)all
Q87. Which of the following process evolved around RNA-
(1) splicing
(2) translation
(3) inital metabolism
(4)all
Q88.DNA resist change by evolving -
(1) Double strand
(2) repair
(3) both 1 and 2
(4) none
Q89. Which is catalytically active-
(1) DNA
(2) RNA
(3) protein
(4) both 2 and 3
Q90 In harshey and chase experiment if blending is not done-
(1) supernatant show radioactivity of sulphur
(2) Supernatant show radioactivity of phosphorus
(3) Pellet show radioactivity from both sulphur and phosphorus
(4) All are correct
Answer key-
46 (2) 47(3) 48(4) 49(2) 50(3) 51(1) 52(4)
53(1) 54(4) 55(4) 56(1) 57(4) 58(4) 59(3) 60(1) 61(1) 62(4) 63(3)
64(4) 65(1) 66(4) 67(4) 68(3) 69(2) 70(1) 71(2) 72(3) 73(1) 74(2)
75(2) 76(1) 77(3) 78(3) 79(4) 80(1) 81(4) 82(4) 83(4) 84(3) 85(3)
86(1) 87(4) 88(3) 89(4) 90(3)
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